The new anti-cholesterol drug being offered on the NHS to prevent heart attacks and strokes

Hundreds of thousands of people are to be offered a cholesterol-lowering drug on the NHS, with estimates predicting it could save 30,000 lives within the next decade.

Inclisiran has been described as a potential “game-changer” and it is hoped it could prevent 55,000 heart attacks and strokes, and save tens of thousands of people from an early death.

Inclisiran will be given as an injection by nurses in GP surgeries across England, with an initial dose followed by another three months later and then twice a year thereafter.

Here is everything you need to know about it.

Who will be given the jab?

The treatment will be given to people with high cholesterol or mixed dyslipidemia – abnormally high levels of fats in their blood – who have already had a heart attack or stroke, under draft final guidance by the National Institute for Health and Care Excellence (Nice).

NHS England said the drug will be rolled out at an unprecedented scale after the health service and drugmakers Novartis struck a deal that enables use of inclisiran at a cost-effective price.

Novartis International AG is a Swiss multinational pharmaceutical company based in Basel, one of the largest pharmaceutical companies in the world.

The “population health agreement” deal could eventually see nearly half a million people benefit from the treatment, helping to prevent 55,000 heart attacks and strokes and potentially saving 30,000 lives in the next decade.

More than two in five people in England have high cholesterol, which puts them at significant risk of developing heart disease, NHS England said, adding that around 6.5 million adults were currently taking lipid-lowering drugs such as statins.

Inclisiran can be used alongside statins, adding to the options available to patients to help control their cholesterol levels.Nice said its recommendation of the drug applies to England and Wales, and inclisiran is also recommended for use in research trials of people who have never had a cardiovascular event.

How does it work?

The drug is the first of a new type of cholesterol-lowering treatment that uses RNA interference (RNAi) to help the liver remove harmful cholesterol from the blood.

Inclisiran lowers the level of a type of fatty substance called LDL-C found in the blood; high levels of LDL-C makes people more likely to suffer a heart attack or stroke.

Nice said clinical trial evidence shows that it might lower levels when other treatments have not reduced them enough.

The health watchdog said while there is no long-term evidence yet on inclisiran’s effect on cardiovascular outcomes, it is considered cost-effective in people who have previously had a cardiovascular event such as a heart attack or stroke and whose cholesterol levels stayed high even after being given other therapies.