New goalkeeper and no striker - Graham Potter explains bizarre Brighton selection at Tottenham
Robert Sanchez, who was on loan at Rochdale last season, will make his Premier League debut as longstanding No 1 Maty Ryan dropped to the bench.
Surprisingly strikers Neal Maupay and Aaron Connolly were omitted from the match day squad with places on the bench for summer arrivals Danny Welbeck and Zeqiri.
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Hide AdLeandro Trossard was preferred as the main striking option with support from Adam Lallana and Pascal Gross.
"Rob comes in," said Potter when asked about his goalkeeper decision.
"He’s a young goalkeeper with some fantastic attributes and we think he can help us in this game.
"It’s a breather for Maty, who has played a lot of football over the last two or three years and I’m looking forward to seeing Rob.
"Leo [Trossard] will play up front, he’s done that role.
"He can score goals and link up play and we have Danny Welbeck and Andi Zeqiri so we have options on the bench."